Though his scientific endeavors continue to inspire awe, few know the entire story of the tumultuous private life of the 20th century’s most brilliant icon, Albert Einstein. Premiering Tuesday April 25, at 9/8c on National Geographic Channel, and in Spanish on Nat Geo Mundo, this new 10-part global event series, GENIUS (GENIUS: EINSTEIN in Spanish)—the channels’ first scripted series — reveals how Albert became Einstein, exploring his extraordinary professional achievements along with his volatile, passionate and complex personal relationships.

From Fox 21 Television Studios, whose recent “The People V. OJ Simpson: American Crime Story” dominated every awards contest and critics’ list, Imagine Television, the producer of “24” and “Friday Night Lights,” and OddLot Entertainment, who earlier this year produced the Academy Award®-  nominated film “Hell or High Water,” the series is based on Walter Isaacson’s book “Einstein: His Life and Universe” and is executive produced by Brian Grazer, Ron Howard and Gigi Pritzker, with Howard making his scripted television directorial debut with the first episode.

Featuring Einstein’s lovers, enemies and fellow scientific luminaries, the all-star cast includes Geoffrey Rush (“The Kings Speech,” “Pirates of the Caribbean,” “Shine”) as the celebrated titular scientist, Johnny Flynn (“Clouds of Sils Maria,” “Song One,” “Lovesick”) as Albert in the years before he rose to international acclaim and Emily Watson (“Theory of Everything,” “The Book Thief”) as his second wife — and first cousin — Elsa Einstein.

GENIUS tracks Einstein’s rise from humble origins as an imaginative, rebellious thinker, through his struggles to be recognized by the establishment, to his global celebrity status as the man who unlocked the mysteries of the cosmos with his theory of relativity. Delving deeper, the series follows Einstein’s alternately exhilarating emotions and heartlessness in dealing with his closest personal relationships, including his children, his two wives and the various women with whom he cheats on them.

Geoffrey Rush as Albert Einstein in National Geographic’s ‘Genius’.

The series is set against an era of global unrest over the course of two world wars. Faced with rising anti-Semitism in Europe, surveillance by spies and the potential for atomic annihilation, Einstein struggles as a husband and a father, not to mention as a man of principle, even as his own life is put in danger.

The series begins in Einstein’s (Flynn) teenage years, when he opposes his father and drops out of school in Germany to go to university in Switzerland. His love of women and passion for theoretical physics blossom after he breaks the heart of his first love, Marie Winteler (Shannon Tarbet, “A Promise,” “Virtuoso”), to pursue his mysterious and elusive fellow physics student, Mileva Maric (Samantha Colley, “Victoria,” “The Crucible”). Their whirlwind romance puts them at odds with teachers and leads to an unexpected pregnancy, forcing both to set aside grand dreams and Einstein to take a mundane job as a patent clerk at the urging of his close friend Michele Besso (Seth Gabel, “Salem,” “Fringe”). Striving in earnest to break into the scientific establishment, Einstein publishes five original papers in one year, catching the eye of many, including the scientist who will go on to become his fiercest adversary, Dr. Philipp Lenard (Michael McElhatton, “Game of Thrones”).

As World War I looms and his marriage begins to crumble, Einstein throws himself into an affair with his first cousin Elsa. Shifting global politics draw him into increasingly politicized scientific circles, causing friction with friends and fellow scientists like Fritz Haber (Richard Topol, “Covert Affairs,” “Elementary”) and Max Planck (Ralph Brown, “Alien 3,” “TURN: Washington’s Spies”). Taking a moral stand, Einstein refuses to support Germany’s war effort. When war descends and borders are shut down, he is prevented from going to his sons in Switzerland when they need him most.

Einstein’s (Rush) fortunes rise after the war when relativity is proven right. On the verge of becoming an overnight celebrity, Elsa (Watson) demands he marry her to avoid the scandal such scrutiny will bring. Fighting with Mileva for a divorce, Einstein also has to contend with the roller coaster of fame. After a tense interview with consulate official Raymond Geist (Vincent Kartheiser, “Mad Men,” “Saints & Strangers”), he escapes a rising tide of anti-Semitism and seeks sanctuary in the United States as an immigrant.

Living and teaching in Princeton, New Jersey, Einstein continues to be besieged on all sides. His fractious relationship with his children and grandchildren weighs on him, he ends up in bed with Russian spy Margarita Konenkova (Ania Bukstein, “Game of Thrones”) and must cope with J. Edgar Hoover’s (T.R. Knight, “Grey’s Anatomy”) personal vendetta to bring him down. He also faces possibly his biggest challenge ever: the pressure to set aside his lifelong pacifism in the hopes of stopping Hitler’s conquest of Europe. While his journey is far from easy, Einstein still manages to find hope and inspiration before his death, in the form of a young girl learning to understand the world. As Einstein famously said, “The important thing is not to stop questioning. Curiosity has its own reason for existing.”

Filmed in Prague, Czech Republic, where Einstein lived and taught early in his career, the series also features a raft of scientific superstars from the turn of the 20th century, including Marie and Pierre Curie, Wilhelm Rontgen, Carl Jung, Werner Heisenberg and more. GENIUS premieres globally in April on National Geographic in 171 countries and 45 languages.

GENIUS is executive produced by Imagine’s Brian Grazer, Ron Howard and Francie Calfo, and co-produced by Anna Culp; showrunner, executive producer and writer is Ken Biller; from OddLot Entertainment, Gigi Pritzker and Rachel Shane are executive producers and Melissa Rucker is co-producer; Sam Sokolow and Jeff Cooney from EUE/Sokolow are also executive producers. Writer Noah Pink, who adapted the series for the screen, is co-executive producer. For National Geographic, Carolyn G. Bernstein is executive vice president and head of global scripted development and production. The series is produced by Fox 21 Television Studios, Imagine Television and OddLot Entertainment.

For more information about the series premiere in English, visit natgeotv.com, and follow us on Instagram and Twitter (@natgeochannel) and for more information about the series premiere in Spanish, visit www.natgeomundo.com and follow us on Facebook (Nat Geo Mundo), Twitter (@natgeomundo) and Instagram (@natgeomundo).